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Supraspinal nocistatin and its amide derivative antagonize the hyperalgesic effects of nociceptin in mice

✍ Scribed by Eugene Hern C. Liu; Yuji Nishiuchi; Terutoshi Kimura; Shinro Tachibana


Book ID
116768349
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
123 KB
Volume
397
Category
Article
ISSN
0304-3940

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## Abstract **BACKGROUND:** Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA a