Supramolecular Structure and Function 8

✍ Scribed by Christiane Schaffitzel, Nenad Ban (auth.), Greta Pifat-Mrzljak (eds.)

• Publisher: Springer US
• Year: 2005
• Tongue: English
• Leaves: 293
• Edition: 1
• Category: Library

✦ Synopsis

An enormous amount of new knowledge on the molecular basis of various biological phenomena has emerged in the rapidly expanding field of bioscience. Since the frontiers in scientific research are difficult to define‚ the creation of new knowledge depends not only on new methods and concepts but also on interaction with other fields of research. The principles and methods of biophysics should be a rational language for discussion not only between scientists of the different disciplines of natural sciences‚ such as physics‚ mathematics‚ biochemistry‚ molecular biology and biotechnology‚ but also for medicine and social sciences as well. This is the general philosophy behind the organization of the Summer Schools organized by Rudjer Institute‚ Zagreb‚ Croatia and the Croatian Biophysical Society. The International Summer Schools on Biophysics have a very broad scope. This is in contrast to the other workshops or schools which are centred mainly on one topic or technique. The intention was to organize courses which provided advanced training at doctoral or postdoctoral level in biosciences. Therefore‚ the Schools essentially have a catalytic role and are complementary to‚ rather than competing with‚ activities of parallel national or international programmes.

✦ Table of Contents

Front Matter....Pages i-viii
Structural Basis of Protein Synthesis....Pages 1-13
The Relationship Between Protein Sequence, Structure and Function....Pages 15-29
Differences in Binding of Stereoisomers to Protein Active Sites....Pages 31-52
Analytical Centrifugation: Looking at Aggregation in Free Solution....Pages 53-71
Time Resolved Protein Fluorescence. Application to Multi-Tryptophan Proteins....Pages 73-98
Novel (Bio)chemical and (Photo)physical Probes for Imaging Living Cells....Pages 99-118
Observing Structure and Dynamics of Membrane Proteins by High-Resolution Microscopy....Pages 119-134
A 2D-Infrared Study of Human Lipoproteins....Pages 135-143
An Introduction to Biological Solid State NMR....Pages 145-156
Multi-Frequency EPR Spectroscopy Studies of the Structure and Conformational Changes of Site-Directed Spin Labelled Membrane Proteins....Pages 157-177
Identification of Protein Structure and its Modifications by Electrospray Mass Spectrometry in Proteomics....Pages 179-197
A Microscopic Study of Disorder-Order Transitions in Molecular Recognition of Unstructured Proteins: Hierarchy of Structural Loss and the Transition State Determination from Monte Carlo Simulations of P27 KIP1 Protein Coupled Unfolding and Unbinding....Pages 199-230
Computational Detection of the Binding Site Hot Spot and Predicting Energetics of Ligand Binding at the Remodeled Human Growth Hormone-Receptor Interface Using a Hierarchy of Molecular Docking and Binding Free Energy Approaches....Pages 231-271
Molecular and Cellular Levels of Biological Evolution....Pages 273-286
Back Matter....Pages 287-293

✦ Subjects

Polymer Sciences;Biochemistry, general;Biophysics and Biological Physics;Animal Anatomy / Morphology / Histology