Supramolecular micelles with dual temperature and redox responses for multi-controlled drug release
β Scribed by Yuan, Weizhong; Zou, Hui; Guo, Wen; Shen, Tianxiang; Ren, Jie
- Book ID
- 120363061
- Publisher
- The Royal Society of Chemistry
- Year
- 2013
- Tongue
- English
- Weight
- 350 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1759-9954
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π SIMILAR VOLUMES
## Abstract A new controlled release polymer micelle was designed and synthesized based on the concept of the βANDβ logic with two orthogonal molecular triggers, namely pH and reduction, for intracellular drug delivery. Specifically, a hydrazine functionalized PEOβ__b__βPMAA block copolymer was use
## Abstract At room temperature, diblock copolymers of PLAβ__b__βPNIPAM and PEGβ__b__βPLA selfβassembled into complex micelles with a PLA core and a mixed PEG/PNIPAM shell. By increasing the temperature, these complex micelles could be converted into a coreβshellβcorona structure composed of a PLA