Supramolecular Architectures Self-assembled from Asymmetrical Hetero Cyclopeptides

✍ Scribed by Si-Yong Qin; Xiao-Ding Xu; Chang-Sheng Chen; Jing-Xiao Chen; Ze-Yong Li; Ren-Xi Zhuo; Xian-Zheng Zhang

• Book ID: 102945299
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 573 KB
• Volume: 32
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.201100052

✦ Synopsis

Abstract

In this study, two asymmetrical cyclopeptides (CP1 and CP2) were designed and synthesized. The self‐assembly behaviors of the asymmetrical cyclopeptides at varying pHs were investigated in terms of transmission electron microscopy (TEM), circular dichroism (CD), and Fourier transform infrared (FT‐IR) spectroscopy. It was found that the self‐assembly of CP1 resulted in the formation of nanofibers with α‐helix conformation, while CP2 self‐assembled into well‐ordered nanorods with anti‐parallel β‐sheet conformation. The strategy demonstrated here presents great potential for preparation of well‐defined nanostructures via rationally designing the molecular structures of cyclopeptides. magnified image