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Suppressor T-cell clones derived from pluripotent stem cells (CFU-GEMM) of a patient with hodgkin's lymphoma

✍ Scribed by Fauser, A. A. ;Bross, K. G. ;Kanz, L. ;L�hr, G. W.

Book ID
104720781
Publisher
Springer-Verlag
Year
1982
Weight
517 KB
Volume
45
Category
Article
ISSN
1432-0584

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✦ Synopsis

Pluripotent stem cells (CFU-GEMM) give rise to multilineage hemopoietic colonies in culture. The cellular composition revealed that mixed colonies contain cells of different myeloid lineages and mononuclear cells with T-cell surface antigens. T-lymphocytes of primary colonies, replated secondary and tertiary colonies from a patient with Hodgkin's Lymphoma were identified by their reaction with the monoclonal antibody OKT 8. Evidence for a common progenitor of myeloid and lymphoid cells is provided by analysis of individual secondary and tertiary colonies using OKT 3, OKT 4, OKT 8, VIM-D 5, and Ig M + D antibodies for each individual colony. Primary mixed, replated secondary and tertiary colonies revealed OKT 8 positive cells. No reaction with OKT 3, OKT 4, VIM-D 5, or Ig M + D was observed.

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