CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta
โฆ LIBER โฆ
Suppressor role of rat CD8+CD45RClow T cells in experimental autoimmune uveitis (EAU)
โ Scribed by Gencheng Han; Hui Shao; Yong Peng; Ping Zhang; Yan Ke; Henry J. Kaplan; Deming Sun
- Book ID
- 113730006
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 582 KB
- Volume
- 183
- Category
- Article
- ISSN
- 0165-5728
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## Depletion of CD8+ Tcells suppresses the development of experimental autoimmune myasthenia gravis in Lewis rats To understand the role of CD8+ T cells in experimental autoimmune myasthenia gravis (EAMG), CD8+ Tcells were depleted by injecting a monoclonal anti-rat CD8 antibody (0x8) into Lewis r