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Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells

✍ Scribed by Catlett, Ian M; Hedrick, Stephen M

Book ID
109923126
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
695 KB
Volume
6
Category
Article
ISSN
1529-2908

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## Abstract Notch1 proteins are involved in binary cell fate decisions. To determine the role of Notch1 in the differentiation of CD4^+^ Th1 versus Th2 cells, we have compared T helper polarization __in vitro__ in naive CD4^+^ T cells isolated from mice in which the N1 gene is specifically inactiva