Suppressor cells of natural killer activity in normal and tumor-bearing individuals
β Scribed by Jussi Tarkkanen; Eero Saksela; Mikko Paavolainen
- Book ID
- 118374288
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 729 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1090-2341
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## Abstract The activity of systemic and __in situ__ natural killer (NK) cells was measured in 3β to 5βweekβold CBA mice with progressively growing murine sarcoma virus (MSV)βinduced tumors. Splenic NK activity was depressed in tumorβbearing mice. NK activity was quite low or not detectable in unfr
Activated killer (AK) cells were generated in spleen-cell cultures derived from tumor-bearing hosts (TS) whereas, under the same conditions, cultured normal spleen cells (NS) gave little cytotoxicity. The AK effectors were primarily Thy1+, AGM1- and Lyt2- and thus were neither classic cytotoxic T ly
Spleen cells from C57BU6J mice bearing Ehrlich carcinoma growing as a solid tumor show progressive unresponsiveness to concanavalin A (Con A) and lipopolysaccharide (LPS) mitogens. This is accompanied by striking spleen enlargement with marked hematopoietic activity. Lymphoproliferative assays of no