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Suppressive Effects of Melatonin on Amyloid-β-induced Glial Activation in Rat Hippocampus

✍ Scribed by Yuxian Shen; Guihong Zhang; Lihua Liu; Shuyun Xu

Book ID
113467043
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
847 KB
Volume
38
Category
Article
ISSN
0188-4409

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## Abstract Minocycline, a second‐generation tetracycline compound, has been examined as a neuroprotectant in β‐amyloid (Aβ)‐injected rat hippocampus. At 7 days post‐injection, Aβ~1‐42~ caused a significant loss of granule cell layer neurons (28% reduction) compared to control uninjected hippocampu