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Suppressive effects of intracellular glutathione on hydroxyl radical production induced by tumor necrosis factor

✍ Scribed by Naofumi Yamauchi; Naoki Watanabe; Hiroshi Kuriyama; Hiroshi Neda; Masahiro Maeda; Takeshi Himeno; Yasushi Tsuji; Yoshiro Nutsu

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
496 KB
Volume
46
Category
Article
ISSN
0020-7136

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✦ Synopsis

Protective effects of intracellular glutathione (GSH) against the cytotoxicity of human recombinant tumor necrosis factor (TNF) were investigated. Three tumor cell lines (L-M, 8-16, H e b ) were used as target cells. Exposure of these cells to buthionine sulfoximine (BSO) or diethyl maleate (DEM) resulted in the depletion of intracellular GSH content to 5.2-43.0% of control values and enhancement of their susceptibility to TNF cytotoxicity. The hydroxyl radical production in L-M cells stimulated by TNF was increased by treatment with BSO or DEM. These results are consistent with the suggestion that intracellular GSH exerts its protective function against the cytocidal effect of T N F by inhibiting the hydroxyl radical production stimulated by TNF.

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