✦ LIBER ✦

Suppressive effects of interleukin-4 and interleukin-10 on the production of proinflammatory cytokines induced by titanium-alloy particles

✍ Scribed by Im, Gun-Il ;Han, Jae-Dong

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 96 KB
Volume: 58
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.1051

No coin nor oath required. For personal study only.

✦ Synopsis

We investigated the effects of two anti-inflammatory cytokines, interleukin (IL)-4 and IL-10, on the production of two proinflammatory cytokines, tumor necrosis factor (TNF)-alpha and IL-6, induced by titanium-alloy (Ti6Al4V) particles. Human monocytes isolated from the peripheral blood of six healthy donors were cultured and exposed to retrieved titanium-alloy particles, together with IL-4 or IL-10. Enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction showed that both IL-4 and IL-10 significantly reduced the production of TNF-alpha and IL-6. The level of TNF-alpha decreased by 74% with IL-4 and 56% with IL-10. The level of IL-6 decreased by 55% with IL-4 and by 66% with IL-10. IL-4 had more consistent suppressive effect on TNF-alpha production. The results from this study provide in vitro evidence of the possible utility of IL-4 and IL-10 in suppression of particle-induced activation of macrophages.

📜 SIMILAR VOLUMES

Effects of interleukin-10 on titanium pa

Effects of interleukin-10 on titanium particle-induced macrophage transcription factor activation and cytokine expressionin vitro

✍ Wong, Neal ;Trindade, Michael C. D. ;Patel, Raj ;Yaszay, Burt ;Goodman, Stuart B 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB

## Abstract This study tests the hypothesis that transcription factor activation by exposure of macrophages to titanium particles can be modulated by the addition of the antiinflammatory cytokine, interleukin 10 (IL‐10). The experiments were carried out with primary human monocyte/macrophages that

Divergent effects of interleukin-10 on c

Divergent effects of interleukin-10 on cytokine production by mononuclear phagocytes and endothelial cells

✍ Marina Sironi; Cecilia Muñoz; Teresa Pollicino; Andrea Siboni; Francesca Luisa S 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 466 KB 👁 1 views

We found that IL-10 has contrasting actions on cytokine production by mononuclear phagocytes and EC.

Inhibition of tumor necrosis factor α–in

Inhibition of tumor necrosis factor α–induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: Distinct targeting in the signaling pathways

✍ Nada Alaaeddine; John A. Di Battista; Jean-Pierre Pelletier; Kayghobad Kiansa; J 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 368 KB 👁 1 views

## Objective: To investigate the effects of the antiinflammatory cytokines interleukin-4 (il-4), il-10, and il-13 on tumor necrosis factor alpha (tnfalpha)-induced prostaglandin e2 (pge2) release in the cellular signaling cascade on human osteoarthritis (oa) synovial fibroblasts. ## Methods: Huma

Effects of the Japanese herbal medicine

Effects of the Japanese herbal medicine “Sho-Saiko-To” (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C

✍ M Yamashiki; A Nishimura; H Suzuki; S Sakaguchi; Y Kosaka 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 399 KB 👁 1 views

"Sho-saiko-to" (TJ-9) consists of 7 herbal components. In Japan, it is widely prescribed to patients with chronic viral liver disease. TJ-9 is known to suppress liver cancer development and possess macrobiotic effects, but its mode of action is not fully understood. This study investigated the follo