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Suppressive effect of interferon-γ on the BCL1 cell-dependent interleukin 5 bioassay

✍ Scribed by Michael Lohoff; Frank Sommer; Martin Röllinghoff

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
237 KB
Volume
19
Category
Article
ISSN
0014-2980

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✦ Synopsis

Suppressive effect of interferon-y on the BCLl celldependent interleukin 5 bioassay*

Proliferation of BCLl cells, generally used for the measurement of murine interleukin (IL) 5, is shown to be strongly suppressed by interferon (1FN)-y. This effect can be abrogated by the addition of anti-IFN-y antibodies. Thus, the IL5 activity of culture supernatants derived from T cells simultaneously producing I F N y and IL5, can only be seen with BCLl cells in the presence of anti-IFN-y antibodies. If anti-IFN-y antibodies are omitted, T cells which produce both, I F N y and IL5, may mistakenly be grouped into the TH1 subtype producing only IFN-y, but no IL 5.

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