Suppression of urate crystal-induced canine joint inflammation by heterologous anti-polymorphonuclear leukocyte Serum
✍ Scribed by Yi-Han Chang; Edward J. Gralla
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- English
- Weight
- 306 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
RATE CRYSTALS have been found in virtually all gouty synovial fluids.ls2 This finding led to the study of inflammatory response to intrasynovial injection of crystals in both and canine' subjects. The urate crystal-induced canine joint inflammation, which closely resembled gouty arthritis, has since been used as a laboratory procedure for evaluating anti-inflammatory agents. It is the only experimental model of inflammation using a non-rodent. Oral administration of phenylbutazone, indomethacin, and intrasynovial injection of glucocorticoids have been shown to prevent or reverse the urate-induced synovitis in
The mechanism whereby urate crystal brings about an acute arthritis is unknown. Phelps and McCarty showed that the urate crystal-induced joint inflammation in the dog was suppressed in animals treated with vinblastine, presumably by the depletion of polymorphonuclear leukocytes (PMN).' It was concluded that polymorphonuclear leukocytes play an essential role in this experimental inflammation. The possibility remains that the vinblastine effects on joint inflammation are mediated by means other than reduction of the number of polymorphs. This study was undertaken to confirm the finding of Phelps and McCarty by comparing the joint response to urate crystals in normal dogs and in dogs made leukopenic by rabbit-antidog-PMN serum.