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Suppression of the Transformed Phenotype in Hybrids of Human T-Cell Leukemia Virus Type I Tax-Transformed Rat Fibroblasts and Normal Human Fibroblasts

✍ Scribed by Hiroshi Inoue; Shoji Yamaoka; Masayuki Imamura; Masakazu Hatanaka


Book ID
115601877
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
753 KB
Volume
215
Category
Article
ISSN
0014-4827

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Somatic cell hybrids were isolated from fusions of diploid embryonic rat fibroblasts with transformed Rat-1 cells which contained 4 to 5 copies of the transforming human Ha-ras 1 gene. In contrast to their transformed parental cells four hybrid clones showed normal morphology, long latency periods o