Suppression of the elicitation phase of contact allergy by epicutaneous application of alpha-l-fucose
✍ Scribed by J. Knop; R. Riechmann
- Book ID
- 104789736
- Publisher
- Springer-Verlag
- Year
- 1982
- Tongue
- English
- Weight
- 212 KB
- Volume
- 274
- Category
- Article
- ISSN
- 0340-3696
No coin nor oath required. For personal study only.
✦ Synopsis
Local application of alpha-L-fucose on the ear before elicitation of contact allergy to dinitrofluorobenzene (DNFB) in BALB/c mice results in a suppression of the contact allergic response. However, local application of alpha-L-fucose at the sensitization site on the abdominal wall before sensitizing the animals with DNFB had no inhibitory effect on contact allergy. Alpha-Lfucose has been demonstrated to inhibit lymphokine activity in vitro and manifestation of cellular immunity in vivo. Our results suggest that alpha-Lfucose suppresses contact allergy by locally inhibiting the efferent phase of the cellular immune response.