Suppression of one monoclonal immunoglobulin in the presence of another in multiple myeloma: Evidence for benign B-cell neoplasia

Novel evidence of a role for chromosome

Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma

✍ Patricia Le Baccon; Dominique Leroux; Christina Dascalescu; Samuel Duley; Daniel 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

## Abstract 1q rearrangement is a remarkably frequent secondary chromosomal change in both non‐Hodgkin's lymphoma (NHL) and multiple myeloma (MM), where it is associated with tumor progression. To gain insight into 1q rearrangement‐associated disease mechanisms, we used fluorescence in situ hybridi