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Suppression of murine retroviral disease by 2′,3′-didehydro-2′,3′-dideoxythymidine (D4T)

✍ Scribed by Robert W. Sidwell; Mick Hitchcock; Kevin M. Okleberry; Roger A. Burger; Reed P. Warren; John D. Morrey


Book ID
118392695
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
707 KB
Volume
19
Category
Article
ISSN
0166-3542

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## Abstract Compound 15 – the 2′‐azido analog of the anti‐HIV compound 2′,3′‐didehydro‐2′,3′‐dideoxythymidine – was synthesized. Treatment of 5′‐__O__‐trityl‐β‐D‐ribofuranosylthymine (1) with DAST or MSTF gave the 2,2′‐anhydro derivative 2. The latter and its 3′‐__O__‐benzoate 3 were used for the s