Suppression of lipopolysaccharide-induced cytokine production of gingival fibroblasts by a soybean, Kunitz trypsin inhibitor

Actinobacillus actinomycetemcomitans lip

Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: A potential role in connective tissue destruction

✍ Charles Bodet; Elisoa Andrian; Shin-ichi Tanabe; Daniel Grenier 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB

## Abstract Fibroblasts, a major constituent of gingival connective tissue, can produce immunoregulatory cytokines and proteolytic enzymes that may contribute to tissue destruction. In this study, we evaluated the production of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), an