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Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

✍ Scribed by Masanobu Oshima; Joseph E Dinchuk; Stacia L Kargman; Hiroko Oshima; Bruno Hancock; Elizabeth Kwong; James M Trzaskos; Jilly F Evans; Makoto M Taketo

Book ID: 117268643
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 1000 KB
Volume: 87
Category: Article
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81988-1

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Damage to the human adenomatous polyposis coli (APC) gene is responsible for not only familial adenomatous polyposis but also many sporadic cancers of the entire digestive tract. Using homologous recombination in embryonic stem cells, we recently constructed gene knockout mice with a truncation muta