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Suppression of IL-2 and IL-4 gene expression by nodularin through the reduced NF-AT binding activity

โœ Scribed by Sung Su Yea; Hwan Mook Kim; Young Jin Jeon; Hee-Mock Oh; Hye Gwang Jeong; Kyu-Hwan Yang


Book ID
119540974
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
329 KB
Volume
114
Category
Article
ISSN
0378-4274

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## Abstract ILโ€4 plays a pivotal role in the development of the Th2 cell mediated humoral immune response and causes IgEโ€dependent allergic inflammatory diseases. Expression of ILโ€4 in differentiated Th2 cells is regulated by transcription factors such as NFโ€AT, APโ€1 and NFโ€IL6. Recently, increasin