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Suppression of Human Pancreatic Cancer Growth in BALB/c Nude Mice by Manumycin, a Farnesyl:protein Transferase Inhibitor

โœ Scribed by Ito, Toshio ;Kawata, Sumio ;Tamura, Shinji ;Igura, Takumi ;Nagase, Toshihiko ;Miyagawa, Jun-ichiro ;Yamazaki, Eiji ;Ishiguro, Hiroshi ;Matsuzawa, Yuji


Book ID
108581312
Publisher
Wiley (Blackwell Publishing)
Year
1996
Tongue
English
Weight
252 KB
Volume
87
Category
Article
ISSN
0910-5050

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โœ Toshihiko Nagase; Sumio Kawata; Shinji Tamura; Yukihiko Matsuda; Yoshiaki Inui; ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 776 KB

So far, treatment with anti-cancer agents has failed to achieve satisfactory results in hepatocellular carcinoma. In the process of hepatocarcinogenesis, ras has been shown to play a role. ras requires a farnesyl moiety for activation. It has been found that UCF I -C (manumycin). an antibiotic, inhi