## Abstract Production of matrix metalloproteinases (MMP) in joint tissue of patients with inflammatory arthritis facilitates cartilage degradation and bone erosion, and leads to joint deformities and crippling. Thus, MMPs are important targets for agents designed to treat inflammatory arthritis. O
Suppression of human monocyte interleukin-1β production by ajulemic acid, a nonpsychoactive cannabinoid
✍ Scribed by Robert B Zurier; Ronald G Rossetti; Sumner H Burstein; Bonnie Bidinger
- Book ID
- 113993371
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 162 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0006-2952
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Interleukin-1 (IL-1) production by periodic acid (H5IO6)-oxidized human peripheral blood mononuclear (PBMN) cells was assessed by the thymocyte co-mitogenesis assay. Maximum IL-1 levels (approximately 1.2 U/ml) in the conditioned media of PBMN cells were registered within the first 24 hrs post-oxida