Suppression of Food Intake in Triatoma infestans by N -Substituted Methyl Maleamates
✍ Scribed by Audino, Paola Gonzalez; Masuh, Hector; de Licastro, Susana A.; Vassena, Claudia; Picollo, María I.; Zerba, Eduardo
- Book ID
- 101216376
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 254 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1526-498X
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✦ Synopsis
A series of methyl esters of N-substituted (Z)-and (E)-maleamic acids were synthesized and their e †ect on food intake measured on Ðfth-instar nymphs of T riatoma infestans. Suppression of food intake was found only for the (Z)isomers. The initial reaction rate of the synthesized compounds with glutathione (GSH) was calculated from the reaction in vitro of the (Z)-isomers. No reaction was observed with the (E)-isomers. Good correlation between the suppression of food intake, measured by its (e †ective dose that inhibited feeding of 50% of ED 50 the population) and the initial reaction rate with GSH and the hydrophobic parameter n, was found.