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Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

✍ Scribed by A. K. Hewson; T. Smith; J. P. Leonard; M. L. Cuzner


Publisher
SP Birkhäuser Verlag Basel
Year
1995
Tongue
English
Weight
549 KB
Volume
44
Category
Article
ISSN
1420-908X

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Studies from our laboratory have shown that region 69-84 (synthetic peptide S49S) of myelin basic protein (MBP) defines an encephalitogenic sequence for experimental allergic encephalomyelitis (EAE) in Lewis rats. The most potent EAE inducers are the guinea pig MBP (Gp-MBP) and region 69-84, known a