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Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1, not stimulation of GATA-2

โœ Scribed by Naoshi Obara; Shigehiko Imagawa; Yoko Nakano; Norio Suzuki; Masayuki Yamamoto; Toshiro Nagasawa


Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
494 KB
Volume
77
Category
Article
ISSN
0340-5761

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## Abstract The ErbB family of receptor kinases is composed of four members: epidermal growth factor receptor (EGFR/ErbB1), ErbB2/neu, ErbB3, and ErbB4. Amplification of the ErbB2/neu is found in about 30% of breast cancer patients and is associated with a poor prognosis. Heregulin (HRG) activates