Suppression of dyskinesias in advanced Parkinson's disease II: Increasing daily clozapine doses suppress dyskinesias and improve Parkinsonism symptoms

Suppression of dyskinesias in advanced P

Suppression of dyskinesias in advanced Parkinson's disease: Moderate daily clozapine doses provide long-term dyskinesia reduction

✍ James P. Bennett Jr.; Elke R. Landow Jr.; Susan Dietrich; Lori A. Schuh 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 517 KB

## Abstract Dyskinesias commonly appear during L‐dihydroxyphenylalanine (L‐DOPA) therapy of advanced Parkinson's disease (PD) and can occur in both dose‐related and dose‐independent patterns. Clozapine exerts a dose‐related suppression of L‐DOPA‐induced dyskinesias by shifting the i.v. L‐DOPA dose‐