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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

โœ Scribed by Hara, Taichi; Nakamura, Kenji; Matsui, Makoto; Yamamoto, Akitsugu; Nakahara, Yohko; Suzuki-Migishima, Rika; Yokoyama, Minesuke; Mishima, Kenji; Saito, Ichiro; Okano, Hideyuki

Book ID
109895815
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
514 KB
Volume
441
Category
Article
ISSN
0028-0836

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โœ Afua Mensah; Claire Mulligan; Jackie Linehan; Sandra Ruf; Aideen O'Doherty; Beat ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› BioMed Central ๐ŸŒ English โš– 971 KB

## Background Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic cause of mental retardation in humans. Among complex phenotypes, it displays a number of neural pathologies including smaller brain size, reduced numbers of neurons, reduced dendritic spin