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Suppression of Absence Seizures by Electrical and Pharmacological Activation of the Caudal Superior Colliculus in a Genetic Model of Absence Epilepsy in the Rat

✍ Scribed by K. Nail-Boucherie; B.T. Lê-Pham; C. Marescaux; A. Depaulis

Book ID
115607809
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
126 KB
Volume
177
Category
Article
ISSN
0014-4886

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Suppression of Absence Seizures by Elect
Suppression of Absence Seizures by Electrical and Pharmacological Activation of the Caudal Superior Colliculus in a Genetic Model of Absence Epilepsy in the Rat
✍ K. Nail-Boucherie; B.T. Lê-Pham; C. Marescaux; A. Depaulis 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 126 KB

Activation of the superior colliculus has been shown to reproduce the antiepileptic effect of the inhibition of the substantia nigra reticulata. A circuit involving neurons of the caudal deep layers of the superior colliculus has been suggested to control brain stem convulsive seizures. The present

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Metabolic approach of absence seizures in a genetic model of absence epilepsy, the GAERS: Study of the leucine-glutamate cycle
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## Abstract We suggest that a dysregulation of energy metabolism in the brain of genetic absence epilepsy rats from Strasbourg (GAERS) could create a specific cerebral environment that would favor the expression of spike‐and‐wave discharges (SWD) in the thalamocortical loop, largely dependent on gl