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Suppression of a Nonsense Mutation in a Mouse Model Of Hurler Syndrome

✍ Scribed by Kim Keeling; Dan Wang; Valery Belakhov; Jeyakumar Kandasamy; Timor Baasov; Su-Chen Li; Yu-Teh Li; Yanying Dai; Sandanandan Velu; David Bedwell; Kim Keeling


Book ID
116989576
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
57 KB
Volume
105
Category
Article
ISSN
1096-7192

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Thirty-five percent of patients with Rett syndrome carry nonsense mutations in the __MECP2__ gene. We have recently shown in transfected HeLa cells that readthrough of nonsense mutations in the __MECP2__ gene can be achieved by treatment with gentamicin and geneticin. This study was performed to tes