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Suppressing Wnt Signaling by the Hedgehog Pathway through sFRP-1

✍ Scribed by He, J.; Sheng, T.; Stelter, A. A.; Li, C.; Zhang, X.; Sinha, M.; Luxon, B. A.; Xie, J.

Book ID
121843992
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2006
Tongue
English
Weight
682 KB
Volume
281
Category
Article
ISSN
0021-9258

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## Abstract Oncogenic activation of the Wnt/β‐catenin signaling pathway is common in hepatocellular carcinoma (HCC). The secreted frizzled‐related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications for carcinogenesis. Promoter hypermethylation of __SFR