## Abstract The mechanisms involved in the loss of nicotinic acetylcholine receptors (nAChRs), seen in brains of patients with Alzheimer's disease (AD) and in cultured cells treated by β‐amyloid peptides (Aβs), remain elusive. We give results to show that lipid peroxidation induced directly by Aβ m
✦ LIBER ✦
Suppressed expression of nicotinic acetylcholine receptors by nanomolar β-amyloid peptides in PC12 cells
✍ Scribed by Z. -Z. Guan; H. Miao; J. -Y. Tian; C. Unger; A. Nordberg; X. Zhang
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 191 KB
- Volume
- 108
- Category
- Article
- ISSN
- 1435-1463
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## Abstract The mechanism for a large loss of neuronal nicotinic acetylcholine receptors (nAChRs) in brains with neurodegenerative diseases remains unclear. Based on our previous results of [^3^H]epibatidine binding influenced by lipid peroxidation, we suggest that nAChR deficit in neurodegenerativ