Preclinical safety testing of DISC-hGMCS
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Peter T. Loudon; Diane M. Blakeley; Mike E. G. Boursnell; Debbie A. Day; Imogen
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Article
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2001
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John Wiley and Sons
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English
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## Background: Disc-hgmcsf is a gh-deleted hsv-2 based vector expressing human gm-csf that is being developed for cancer immunotherapy. to support first clinical use, a range of preclinical safety studies were performed using disc-hgmcsf in addition to disc-murine-gmcsf and the backbone vector, ta-