Supported liquid membrane extraction of urinary trans, trans-muconic acid, a biomarker for benzene exposure
✍ Scribed by Jan Norberg; Degu Tiruye; Lennart Mathiasson; Jan Åke Jönsson
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 110 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1615-9306
No coin nor oath required. For personal study only.
✦ Synopsis
Supported liquid membrane extraction of urinary trans, trans-muconic acid, a biomarker for benzene exposure
In this study, sample preparation of urinary trans, trans-muconic acid (tt-MA), a minor metabolite and biomarker of benzene, by means of Supported Liquid Membrane (SLM) extraction has been investigated. The sample extract was automatically transferred on-line to an ion exchange chromatographic column and the analytes were detected using a photodiode array detector. Automation of the system was accomplished using a robotic sample preparation processor integrated into the chromatographic system. Detection limits calculated from the baseline noise was in the subppb range, and quantification of tt-MA is safe down to 10 ppb.