Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia
β Scribed by Williams, N M; Preece, A; Spurlock, G; Norton, N; Williams, H J; Zammit, S; O'Donovan, M C; Owen, M J
- Book ID
- 110059652
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 68 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1359-4184
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## Abstract Chromosome 8p21β12 has been reported to be a susceptibility locus for schizophrenia based on genomeβwide linkage scans. After neuregulin 1 (__NRG1__) was identified as a positional candidate gene for schizophrenia in this locus, several independent association studies have reported cont
## Abstract There is now strong evidence that Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia. NRG1 mediates some of its effects through the tyrosine kinase receptor erbB4, and analysis of gene knockβout animals suggests that the functional interaction of NRG1 and erbB4 mediates beha