This new edition textbook continues down the path that the first edition, winner of the 2013 IISE/Joint Publishers Book-of-the-Year Award, successfully carved out. The textbook targets engineering students and emphasizes the use of operations research models and solution methods important in the design, control, operation, and management of global supply chains. Completely updated, Supply Chain Engineering: Models and Applications, Second Edition stresses quantitative models and methods, highlights global supplier selection and vendor risk management techniques, and discusses the use of multiple criteria decision-making models in supply chain management. The new edition includes chapters on health and humanitarian supply chains, including disaster management and logistics modeling, and on warehousing and distribution. Disruptions to global supply chains due to the COVID-19 pandemic are discussed throughout the book. Industry and government strategies to make the global supply chains resilient are also presented. Thirty four case studies have been included to illustrate various supply chain models and methods. Exercises are included at the end of each chapter, and a solutions manual and PowerPoint slides are available for qualified textbook adoptions. The new edition continues to target upper-level undergraduate and graduate students in engineering, as well as MBA students in operations management, logistics, and supply chain management programs that emphasize quantitative analysis. It is also useful as a reference for technical professionals and researchers in industrial engineering, supply chain management, procurement, logistics and health administration.