Time-course of the cannabinoid receptor
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Julián Romero; Fernando Berrendero; Jorge Manzanares; Alberto Pérez; Javier Corc
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Article
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1998
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John Wiley and Sons
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English
⚖ 263 KB
👁 2 views
Recent studies have demonstrated that the pharmacological tolerance observed after prolonged exposure to plant or synthetic cannabinoids in adult individuals seems to have a pharmacodynamic rather than pharmacokinetic basis, because downregulation of cannabinoid receptors was assessed in the brain o