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Supersaturation Produces High Bioavailability of Amorphous Danazol Particles Formed by Evaporative Precipitation into Aqueous Solution and Spray Freezing into Liquid Technologies

โœ Scribed by Vaughn, Jason M.; McConville, Jason T.; Crisp, Matthew T.; Johnston, Keith P.; Williams, Robert O.


Book ID
123615369
Publisher
Informa plc
Year
2006
Tongue
English
Weight
144 KB
Volume
32
Category
Article
ISSN
0363-9045

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Rapid dissolution of high-potency danazo
โœ Xiaoxia Chen; Jason M. Vaughn; Miguel J. Yacaman; Robert O. Williams III; Keith ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 188 KB

High-potency danazol particles with high dissolution rates were produced by evaporative precipitation into aqueous solution (EPAS). Aqueous suspensions formed by EPAS were centrifuged to remove the nonadsorbed surfactant. The resulting surfactant-coated drug particles had extremely high drug-to-surf