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Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system

✍ Scribed by Tobias Neuberger; Bernhard Schöpf; Heinrich Hofmann; Margarete Hofmann; Brigitte von Rechenberg

Book ID
113723732
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
196 KB
Volume
293
Category
Article
ISSN
0304-8853

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✦ Synopsis

Nanoparticles can be used in biomedical applications, where they facilitate laboratory diagnostics, or in medical drug targeting. They are used for in vivo applications such as contrast agent for magnetic resonance imaging (MRI), for tumor therapy or cardiovascular disease. Very promising nanoparticles for these applications are superparamagnetic nanoparticles based on a core consisting of iron oxides (SPION) that can be targeted through external magnets. SPION are coated with biocompatible materials and can be functionalized with drugs, proteins or plasmids. In this review, the characteristics and applications of SPION in the biomedical sector are introduced and discussed.

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