In order to study the signal transduction mechanism of human endothelial cells (EC), the regulation of superoxide anion (02-)release in EC has been investigated using the calcium ionophore A23187 and phorbol myristate acetate (PMA), a potential activator of the Ca2+ activated, phospholipid-dependent
โฆ LIBER โฆ
Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore
โ Scribed by John M. Robinson; John A. Badwey; Manfred L. Karnovsky; Morris J. Karnovsky
- Book ID
- 117056457
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 308 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0006-291X
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The phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the calcium ionophore, A23187, have similar effects on many different cells. For example, both show mitogenic and comitogenic activities for lymphocytes. It had been suggested that some of TPA's effects are due to its ab