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Superoxide-induced apoptosis of activated rat hepatic stellate cells

✍ Scribed by Chinnasamy Thirunavukkarasu; Simon Watkins; Stephen A.K. Harvey; Chandrashekhar R. Gandhi

Book ID
116650421
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
384 KB
Volume
41
Category
Article
ISSN
0168-8278

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## Abstract Reactive oxygen species (ROS) activate retinoid‐containing quiescent hepatic stellate cells (qHSCs) to retinoid‐deficient fibrogenic myofibroblast‐like cells (aHSCs). However, ROS also cause apoptosis of aHSCs, and apoptotic aHSCs are observed in inflammatory fibrotic liver. Here, we in