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Superoxide generation in v-Ha-RAS transduced human keratinocytes: Ji-Qin Yang, Shijun Li, Frederick E. Domann, Garry R. Buettner and Larry W. Oberley, Free Radical & Radiation Biology Program, B180 ML, The University of Iowa, Iowa City, IA 52242

Book ID: 114278060
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 152 KB
Volume: 27
Category: Article
ISSN: 0891-5849
DOI: 10.1016/s0891-5849(99)90730-x

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The oncogenic ras protein controls signal-transduction pathways that are critical for cell proliferation and tumorigenesis. Here, we demonstrate that v-Ha-ras ±transduced human keratinocyte HaCaT cells produced significantly larger amounts of superoxide than did control cell lines. The superoxide ge