## Communicated by Francesco Giannelli (NCV) were in the normal range, and there was no finding of nerve conduction block. His younger brother had also been affected by MND. He had developed muscle weakness of the right upper limb at age 52, followed by muscle weakness and atrophy of all limbs, an
✦ LIBER ✦
Superoxide dismutase (glu100 → gly) in a family with inherited motor neuron disease: detection of mutant superoxide dismutase activity and the presence of heterodimers
✍ Scribed by Calder, Victoria L.; Domigan, Neil M.; George, Peter M.; Donaldson, Ivan M.; Winterbourn, Christine C.
- Book ID
- 122420376
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 410 KB
- Volume
- 189
- Category
- Article
- ISSN
- 0304-3940
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## Abstract Caloric restriction (CR) prolongs lifespan in insects, rodents, and nonhuman primates, a process attributed to a reduction in oxidative stress. Transgenic mice that overexpress the mutant human Cu/Zn‐superoxide dismutase (__SOD1__) gene (G93A mice) are an animal model of amyotrophic lat