Superoxide dismutase and hydrogen peroxide cause rapid nitric oxide breakdown, peroxynitrite production and subsequent cell death

A dibenzoylmethane derivative protects a

A dibenzoylmethane derivative protects against hydrogen peroxide-induced cell death and inhibits lipopolysaccharide-induced nitric oxide production in cultured rat astrocytes

✍ K. Takano; K. Sugita; M. Moriyama; K. Hashida; S. Hibino; T. Choshi; R. Murakami 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 741 KB

Activation of glia has been observed in various neurodegenerative diseases. Excessive production of nitric oxide (NO), as a consequence of increased inducible nitric oxide synthase (iNOS) in glia, contributes to the neurodegeneration. The enhancement of intracellular stresses such as oxidative stres