The chromosomal origins and in some cases the molecular composition of 26 autosomal supernumerary marker chromosomes (SMC) were identified using combined fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) techniques. Fifteen were de novo, 4 maternally and 2 paternally tran
Supernumerary marker 15 chromosomes: a clinical, molecular and FISH approach to diagnosis and prognosis
β Scribed by John A. Crolla; John F. Harvey; Fiona L. Sitch; Nick R. Dennis
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 956 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0340-6717
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Using fluorescence in situ hybridization (FISH), supernumerary marker chromosomes (SMC) from all the human autosomes except chromosome 5, have now been described, most being derived from the acrocentric autosomes. This review summarizes the results of 168 cases of autosomal SMC excluding those from
## Abstract The unstable, geneβrich chromosome region 17p11.2βp12 is associated with various structural aberrations including supernumerary marker chromosomes (SMCs). In some cases, SMC(17)s utilize the same substrates for recombination as the common recurrent 17p11.2 and 17p12 rearrangements. We r