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Supernumerary chromosome inherited from a maternal balanced translocation leading to pure trisomy 9p

✍ Scribed by Tihy, Fr�d�rique; Lemyre, Emmanuelle; Dallaire, Louis; Lemieux, Nicole

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 18 KB
Volume: 91
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(20000424)91:5<383::aid-ajmg12>3.0.co;2-g

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✦ Synopsis

We describe a child with a supernumerary chromosome defined as der(9)t(9;22) (q12;p11), resulting in trisomy 9p and trisomy 22p. The mother carried the balanced translocation. In G- and C-banding the derivative chromosome 9 appeared to be dicentric and to contain 22q material. Using in situ hybridization we defined the exact breakpoints of the translocation and ruled out the possibility of a centric fission in the mother's chromosomes.

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