Tardive dyskinesia can be suppressed by drugs that block dopaminergic receptors, but often at the cost of a concomitant increase in parkinsonism. Sulpiride (400 -- 2100 mg/day), a selective type-2 dopamine receptor antagonist, was evaluated in a blind, placebo-controlled trial in 11 patients with ta
Sulpiride-induced tardive dystonia
โ Scribed by Lucinda G. Miller; Dr. Joseph Jankovic
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 224 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
Sulpiride is a selective D2โreceptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyramidal side effects, sulpirideโinduced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a 37โyearโold man who developed persistent segmental dystonia within 2 months after starting sulpiride therapy. We could not find any previous reports of sulpirideโinduced tardive dystonia.
๐ SIMILAR VOLUMES
## Abstract After cessation of longโterm treatment with haloperidol, a 77โyearโold man developed severe dyskineticโdystonic movements involving mainly the tongue and associated also with oromandibular dystonia and blepharospasm that were manifested exclusively during the process of eating and that