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Sulpiride-induced QTC prolongation and hERG channel blockade

✍ Scribed by Jin Zhai; Dave Reynolds; Gregory Friedrichs; Ying-Ying Zhou

Book ID: 113941760
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 56 KB
Volume: 60
Category: Article
ISSN: 1056-8719
DOI: 10.1016/j.vascn.2009.04.193

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## Abstract Prolongation of the QT interval of the electrocardiogram is a typical effect of Class III antiarrhythmic drugs, achieved through blockade of potassium channels. In the past decade, evidence has accrued that several classes of drugs used for non‐cardiovascular indications may prolong the