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Sulpiride in negative schizophrenia: A placebo-controlled double-blind assessment

✍ Scribed by S. D. Soni; A. Mallik; A. A. Schiff

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 505 KB
Volume: 5
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470050308

No coin nor oath required. For personal study only.

✦ Synopsis

Twenty-four chronic schizophrenic long-stay hospital patients were identified, who had not received neuroleptic drugs for 8-30 (average 8 months) and met or exceeded a minimum criterion of severity of negative symptoms. They were randomly allocated to either sulpiride 200 mg twice daily or matching placebo, on a double-blind basis for 12 weeks. The results showed that low-dose sulpiride was significantly better than placebo in relation to improvements in negative symptoms. The changes in social behaviour were complex and not obviously related to symptom improvement; exhibited abnormal behaviour, a major factor in preventing successful return to the community, consistently improved only on the active drug.

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