Glucuronidation of oxazepam is not spare
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Jesper Sonne; Per Buch Andreasen; Steffen Loft; Martin DΓΈsing; Frederik Andrease
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Article
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1990
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John Wiley and Sons
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English
β 621 KB
The disposition of oral oxazepam was investigated in seven patients with decompensated cirrhosis and encephalopathy and in nine healthy individuals to further examine the hypothesis of preservation of glucuronidation in liver disease. The patients showed a severe reduction in the quantitative liver