This study examines the transcriptional response of human epidermal keratinocytes (HEK) to sulfur mustard (HD) in order to gain a better understanding of the intracellular events that result in cytotoxicity. Differential display polymerase chain reaction technology was used to examine the relative t
Sulfur mustard vapor effects on differentiated human lung cells
β Scribed by Seagrave, JeanClare; Weber, Waylon M.; Grotendorst, Gary R.
- Book ID
- 121299822
- Publisher
- Informa plc
- Year
- 2010
- Tongue
- English
- Weight
- 830 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0895-8378
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π SIMILAR VOLUMES
Sulfur mustard (SM) is known to induce cutaneous injury and to cause acute damage to the respiratory tract. Although skin vesication has been demonstrated on human epidermal keratinocytes in culture, no study has been carried out to analyze the effects of SM on the ultrastructural and functional act
The ability of sulphur mustard (HD) to induce DNA damage places limits on the efficacy of approaches aimed at protecting human cells from the cytotoxic effects of HD using a variety of protective agents such as thiol-containing esters and protease inhibitors. In the present study, potential alternat
## Abstract __In vivo__ experiments have shown that melanocytes are more sensitive than keratinocytes to the cytotoxic effects of sulfur mustard when it is applied topically to pig skin.1 It has been hypothesized that this is caused by the uncoupling of the melanogenic pathway by depletion of cellu